Rajeshkumar et al. World Journal of Pharmacy and Pharmaceutical Sciences. ANTICANCER ACTIVITY OF ANDROGRAPHIS PANICULATA. showing anticancer activity on HEp2 – Human larynx carcinoma cell lines in-vitro KEYWORDS: Andrographis paniculata,Herbal medicine. A refined extract of A. paniculata, also significantly reduces activities of lipid .. The anticancer activity was observed due to the presence of andrographolide.
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The effects of salinity levels on the measured physiological and phytochemical traits among tolerant and sensitive accessions of A. In this regard, our results indicated that proline as well as the AG and NAG contents is positively correlated with the substrate concentration of salt, in which the tolerant accessions were higher in proline, AG, and NAG contents compared with the sensitive ones. Components of variance and broad-sense heritability of studied characters in A.
However, to prove their efficacy for clinical utilization more scientific data are needed. The antioxidant phytochemicals protect the cells from oxidative damage.
Plant-derived compounds act as a prevention within the development of many anti-cancer agents. The extracts were then stored below ambient temperature for further studies. This event complies with the hypothesis that the A. View at Google Scholar Acivity. View at Google Scholar H. Maintained cultures were passage weekly and the culture medium was changed twice a week.
Effect of silymarin on different acute inflammation models and on leukocyte migration. However, we are totally aware that not any correlation does imply causation, yet we believe that in this particular case and according to the previous experiences, our observations are in agreement with the concept of a close relationship between the availability of the secondary metabolites and self-defense systems of the plant species against abiotic stresses.
Previous studies have demonstrated that the ability of A.
The results obtained in the study indicate that A. Anticancer activity of combinational effects of A.
Under the low level of salinity, the salt ions inhibited the biosynthesis of phytochemicals as indicated by the decrease in their amounts in both tolerant and sensitive accessions.
To the best of our reference, the only conducted research related to salt stress in A. Vertical bars represent standard error of mean for three samples. Analysis of variance showed high significant differences among the accessions for AG and NAG contents.
Silybum marianum is an annual or biennial erect herb belongs to the family Compositae. Reportedly, improving the content of some phytochemicals such as flavonoids as one of the most important pharmaceutical contents could be enhanced through salinity and drought stresses [ 121415 ].
The authors of the paper declare that they do not have any direct financial relation with the commercial identities mentioned anticsncer the present paper that might lead to conflict of interests panicylata any of the authors. Journal of Pharmacology and Toxicology Volume 8 1: The trend of proline and the three main phytochemicals in tolerant accession were linear and positive, while in sensitive accession they were nonlinear.
By this time, the tolerant accession also had significantly higher proline and phytochemical contents and less leaf necrosis than sensitive accession Ten Hoopen, and J. Natural drugs have less toxicity than the commercially available drugs. However, this should not be interpreted in the way that saline water and soil are suggested as an alternative solution to increase the production of A. These neutral organic compounds can also improve the inhibitory effects of high ion androographis on enzymatic activity without interfering with protein structure and function [ 35 ].
The human tumor cytotoxicity was determined by the protocols established by NCI Monks et al. Chemotherapy is a major clinical treatment used for the control of advanced stages of malignancies and metastasis.
All chemicals used were of analytical grade. These salinities were applied using Therefore, the stress conditions have a strong impact on the responsible metabolic pathways for the accumulation of the related natural products [ 11 ]. The solvent extract was concentrated under reduced pressure using a rotary evaporator.
D and confirmed at Botany Department, Dr. By contrast, among the accessions, the highest TDW As in cancer cells the tumor suppressor genes E-cadherin and P shows the down regulation but while treating with the leaf extract of Andrographis paniculata the genes show up-regulation.
Whatman filter paper no. Variations due to paniculatz levels SL and accessions AC were highly significant. The following drugs and chemicals were used: For example, the level of metabolites was increased in the leaves of salt-treated plants such as Arabidopsis thaliana [ 4 ], Oryza sativa [ 5 ], Hordeum vulgareDatura inoxiaGlycine maxTriticum aestivum [ 5 ], and Catharanthus roseus [ 6 ]. Five human cancer cell lines i. Table of Contents Alerts.
The annticancer B SRB assay was used to assess growth inhibition of human tumor. The day seedlings were transferred from jiffy media into the pot with sand medium. These medicinal plant s possess good immunomodulatory and antioxidant properties, leading to anticancer aandrographis. The plant extracts showed potent hepatoprotective Trivedi and Rawal,vermicidal Singh et al. The plant extract contains three major groups of phytochemical compounds, namely, diterpenes, flavonoids and stigmasterols [ 16 ].