Read the Patient/Caregiver Information Leaflet provided by your pharmacist before (including prescription drugs, nonprescription drugs, and herbal products). Diastat. This web page is intended as quick reference of limited prescribing information for this product. This is not intended to represent a comprehensive. The syringe(s) should be labeled with appropriate information including the .. Avoid prescribing opiate cough medications in patients taking benzodiazepines.
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Moderate Coadministration of oritavancin and diazepam may result in increases or decreases in diazepam exposure and may increase side effects or decrease efficacy of diazepam. Lower doses of one or informstion agents may be required.
For example, the concomitant use of barbiturates and benzodiazepines increases sleep duration and may contribute to rapid onset, pronounced CNS depression, respiratory depression, or coma when combined with sodium oxybate. In general, diazepam should be used with caution in patients with a neuromuscular disease, such as muscular dystrophy, myasthenia gravis, or myotonia as these conditions can be exacerbated.
Moderate Monitor for increased diazepam-related adverse reactions including sedation and respiratory depression if coadministration with crizotinib is necessary. Moderate In premarketing studies, zaleplon potentiated the CNS effects of ethanol, imipramine, and thioridazine for at least 2 to 4 hours. Monitor for an increase in CNS or respiratory depression. Educate patients about the risks and symptoms of respiratory depression and sedation. Moderate Consider a dose reduction of diazepam as clinically appropriate, if adverse reactions occur when administered with cannabidiol.
For Intermezzo brand of sublingual zolpidem tablets, reduce the dose to 1.
Although diazepam is effective in preventing recurrent febrile seizures, due to the risk of adverse events and the lack of long term complications from simple febrile seizures, the American Academy of Pediatrics does not recommend routine use of intermittent diazepam for febrile seizure prophylaxis.
Predictions regarding this interaction can be made based on the metabolic pathways of these drugs. Diazepam is a substrate of the hepatic isoenzyme CYP3A4; isavuconazole, the active moiety of isavuconazonium, is a moderate inhibitor of this enzyme.
Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine: Ambulatory patients receiving diazepam should be warned of the hazards of driving or operating machinery, and should avoid engaging in these activities until the full effect of the drug has dissipated.
Use these drugs cautiously with MAOIs; warn patients to not drive or perform other hazardous activities until they know how a particular drug combination affects them. Not recommended as a distat agent due to sodium benzoate and benzoic acid in the injection see Precautions and How Supplied.
A dose reduction of diazepam may be necessary. Drugs that can cause CNS depression, if used concomitantly with vigabatrin, may increase both the frequency and the intensity of adverse effects such as drowsiness, sedation, and dizziness.
The available doses from the 20 mg delivery system are 10 mg, Oral, parenteral, or rectal long-acting benzodiazepine Used for anxiety, acute alcohol withdrawal, skeletal muscle spasm, disatat seizure disorders Long-term use not well studied.
Patients should be monitored for needed dosage adjustments in accordance with response. Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine: If a benzodiazepine must be used in a patient with a history of falls or fractures, consider reducing use of other CNS-active medications that increase the risk of falls and fractures and implement other strategies to reduce fall risk.
Major Monitor for diazepam-related adverse reactions including sedation and respiratory depression if coadministration with ceritinib is necessary due to increased diazepam exposure.
Minor No specific drug interactions were identified with systemic agents and apraclonidine during clinical trials. Moderate Concomitant administration can potentiate the CNS effects e. Large quantities of benzodiazepines should not be prescribed for patients with known suicidal ideation or a history of suicide attempt.
Caution should be used when paliperidone is given in combination with other centrally-acting medications including anxiolytics, sedatives, and hypnotics, buprenorphine, butorphanol, dronabinol, THC, ethanol, nabilone, nalbuphine, opiate agonists, and pentazocine.
Clarithromycin could theoretically inhibit the CYP3A4-mediated metabolism of oxidized benzodiazepines, such as diazepam.
If used with a benzodiazepine, droperidol should infotmation initiated at a low dose and adjusted upward, with caution, as needed to achieve the desired effect. Aluminum Hydroxide; Magnesium Hydroxide; Simethicone: Moderate The plasma concentrations of diazepam may be elevated when administered concurrently with cobicistat. Major Any substances that act on the CNS, including psychoactive drugs and drugs used as anesthetic adjuvants e. Dosage must be individualized.
Benzodiazepines may also cause incoordination or paradoxical reactions that may worsen symptoms of Parkinson’s disease. The manufacturer, however, notes that diazepam is not useful as sole therapy and may not be effective as adjunctive therapy for longer than 4 months.
The concurrent use of eszopiclone with other anxiolytics, sedatives, and hypnotics at bedtime or in the middle of the night is not recommended.